NextPoint | Expanding the Potential of Immunotherapy

expanding the potential
of immunotherapy

One pathway,
many possibilities

NextPoint is advancing the field of immuno-oncology through its leading scientific work on the novel HHLA2 pathway. Our innovative approach integrates foundational science with a defined clinical biomarker to deliver a new class of monotherapies for patients who will not benefit from PD-1/L1 inhibitors. Our team of proven drug developers is working closely with our renowned scientific founders to launch a new world of precision immuno-oncology.

world-class team.

scientific
founders.

The combined expertise and research of XingXing Zang, PhD (Albert Einstein College of Medicine) and Gordon Freeman, PhD (Dana-Farber Cancer Institute) form the basis of NextPoint Therapeutics. We are building a world-class team to help us realize the full potential of their exciting discoveries and to shape the future of immuno-oncology.

XingXing Zang, PhD

Albert Einstein College of Medicine

Gordon Freeman, PhD

Dana-Farber Cancer Institute

leadership.

investors & partners.

news.

March 21, 2023

Axel Hoos, MD, PhD, Joins NextPoint Therapeutics Board of Directors

February 21, 2023

NextPoint Therapeutics Appoints Leena Gandhi, MD, PhD, as Chief Medical Officer

January 10, 2023

NextPoint Therapeutics Announces $80 Million Series B Financing co-led by Leaps by Bayer and Sanofi Ventures to Advance Novel Immuno-Oncology Programs

What’s NEXT for you?

Vice President Translational Science

Associate Director/Director, Clinical Operations

Research Associate

LabCentral, 238 Main Street, 5th Floor, Cambridge, MA 02142

Axel Hoos, MD, PhD, Joins NextPoint Therapeutics Board of Directors

Cambridge, MA – March 21, 2023 – NextPoint Therapeutics, a biotechnology company developing a new world of precision immuno-oncology, announced today that Axel Hoos, MD, PhD, has joined the NextPoint Board of Directors. Dr. Hoos currently serves as the Chief Executive Officer of Scorpion Therapeutics and brings a wealth of business, entrepreneurial and biopharmaceutical research and development expertise to the role.

“Dr. Hoos is a recognized pioneer in immuno-oncology and has shaped the checkpoint therapeutic landscape through his work on a new development paradigm for IO medicines and the development of the anti-CTLA-4 antibody ipilimumab, the first FDA-approved checkpoint immunotherapy,” commented Detlev Biniszkiewicz, PhD, CEO of NextPoint Therapeutics. “Our team will benefit greatly from Dr. Hoos’ expertise and perspective as we advance our novel immuno-oncology programs targeting the HHLA2 pathway to the clinic.”

“Immuno-oncology has become a critical component in our treatment armamentarium for cancer patients, and scientists are seeking the next breakthrough medicine to further expand its reach. I am looking forward to working with the executive team and fellow Board members to help NextPoint realize its promise to deliver the next IO breakthrough,” said Dr. Hoos. “NextPoint’s work on the HHLA2 pathway has the potential to expand the reach of precision immuno-oncology to a range of patients who do not benefit from currently available therapies.”

Prior to becoming CEO of Scorpion, Dr. Hoos served as Senior Vice President, R&D Governance Chair, and Therapeutic Area Head for Oncology at GlaxoSmithKline Pharmaceuticals (GSK). In that role, Dr. Hoos built the Oncology business across all therapeutic modalities in the focus areas of immuno-oncology, synthetic lethality, tumor cell targeting, epigenetics, and cell & gene therapy. He is a member of the Board of Trustees at the Sabin Vaccine Institute, Director on the Board of TCR2, and member of the Scientific Advisory Board and Co-Director of the Cancer Immunotherapy Consortium at the Cancer Research Institute. Dr. Hoos received his MD in Medicine from Heidelberg University, and his PhD in Molecular Oncology from the German Cancer Research Center. He trained in general surgery at the Technical University of Munich and as a fellow in cancer research at Memorial Sloan-Kettering Cancer Center.

About NextPoint Therapeutics

Media Contact

Chelsea Rule
MacDougall Advisors
crule@macdougall.bio

NextPoint Therapeutics Appoints Leena Gandhi, MD, PhD, as Chief Medical Officer

Cambridge, MA – February 21, 2023 – NextPoint Therapeutics, a biotechnology company developing a new world of precision immuno-oncology, announced today the appointment of Leena Gandhi, MD, PhD, as Chief Medical Officer (CMO).

As CMO, Dr. Gandhi will oversee the clinical development of NextPoint’s precision immuno-oncology programs that target the newly discovered HHLA2 pathway to activate anti-tumor immune responses. Dr. Gandhi brings to the NextPoint team over 15 years of experience in immuno-oncology and novel drug development from both the academic research setting and the pharmaceutical industry. She has led pivotal studies demonstrating the utility of PD-L1 as a biomarker for efficacy of anti-PD1 agents in lung cancer as well as studies demonstrating the value of combining immunotherapy and chemotherapy in the treatment of non-small cell lung cancer.

“Leena is a proven leader in immuno-oncology and a brilliant physician-scientist, and our team will benefit greatly from her academic and drug development expertise as NextPoint moves forward in its next stage of growth,” said Detlev Biniszkiewicz, PhD, Chief Executive Officer of NextPoint Therapeutics. “We thank Dr. Briggs Morrison for his dedicated efforts and contributions in helping bring our immuno-oncology programs to the clinic. Briggs Morrison, MD, will step down as Interim CMO, but will continue to advise the company on an ongoing basis.”

“I look forward to working with the NextPoint team to accelerate the development of programs targeting the HHLA2 pathway, a novel tumor-suppressive mechanism with the potential to impact many patients,” commented Dr. Gandhi. “NextPoint’s outstanding team of scientists who have characterized the HHLA2 pathway along with experienced drug developers in the management team makes for the ideal chemistry to usher these novel immuno-oncology programs into the clinic.”

Dr. Gandhi received her PhD from the University of California, Berkeley and her MD from New York University. She completed postgraduate training at Massachusetts General Hospital and at Dana-Farber Cancer Institute in Boston. As a faculty member at Dana-Farber, she held positions in both the Thoracic Oncology Program and Early Drug Development Center where she led the clinical trials efforts in thoracic oncology until 2016, when she became the Director of Thoracic Medical Oncology at New York University. In Dr. Gandhi’s next role as Vice President of Immuno-Oncology Development at Eli Lilly, she led the development of novel immuno-oncology agents across cancer types before returning to Dana-Farber in 2020, where she most recently served as the Director of the Center for Cancer Therapeutic Innovation a cross-malignancy novel therapeutics hub.

About NextPoint Therapeutics

Contacts

Media Contact

Lauren Arnold
MacDougall Advisors
1(617)694-5387
larnold@macdougall.bio

NextPoint Therapeutics Announces $80 Million Series B Financing co-led by Leaps by Bayer and Sanofi Ventures to Advance Novel Immuno-Oncology Programs

Programs target the novel HHLA2 pathway, activating anti-tumor immune responses to find and destroy cancer cells

Cambridge, MA / Leverkusen, Germany – January 10, 2023 – NextPoint Therapeutics, a biotechnology company developing a new world of precision immuno-oncology, announced today that it raised $80 million in Series B financing co-led by Leaps by Bayer, the impact investment arm of Bayer AG, and Sanofi Ventures, the strategic venture capital arm for Sanofi. The financing will be used to advance NextPoint’s two lead precision immuno-oncology programs into the clinic, both targeting the newly discovered HHLA2 pathway to activate anti-tumor immune responses.

Additional new investors in the round include Invus, Catalio Capital Management, Sixty Degree Capital and PagodaTree Partners. Existing investors that took part in the financing include MPM Capital Management, Dana-Farber Cancer Institute’s Binney Street Capital and NextPoint founder Gordon Freeman, PhD. As part of the financing, Rakhshita Dhar, Senior Director of Venture Investments Health at Leaps by Bayer, and Paulina Hill, Partner at Sanofi Ventures, will join the NextPoint Board of Directors.

NextPoint’s programs aim to deliver monotherapies for cancer patients without viable treatment options. While immune checkpoint inhibitors targeting PD-1/L1 have revolutionized cancer treatments, many patients do not benefit from these medications and require novel therapeutic strategies. Similar to PD-L1, the tumor antigen HHLA2 is a member of the B7 receptor family¹, is highly expressed on certain hard-to-treat cancers², and drives avoidance of detection from the immune system. Importantly, HHLA2 is independent of PD-L1 and is often most strongly expressed in PD-L1-negative cancers. NextPoint’s approach re-activates immune cells in tumors that are suppressed by HHLA2-driven immune evasion.

NextPoint originated from the combined expertise of its academic founders, Gordon Freeman, PhD, of the Dana-Farber Cancer Institute, and XingXing Zang, PhD, of Albert Einstein College of Medicine. Drs. Freeman’s and Zang’s independent discovery and characterization of the HHLA2 pathway formed the basis of the NextPoint approach. The company and its founders have shown in preclinical models and with analysis of existing clinical datasets that the HHLA2 pathway is an important tumor-suppressive mechanism in many patients^3,4.

“NextPoint is building a deep understanding of the HHLA2 tumor-specific immune-escape mechanism, with the ultimate goal of establishing standalone treatments in cancers with high HHLA2 expression,” said Detlev Biniszkiewicz, PhD, Chief Executive Officer of NextPoint Therapeutics. “The support of our new investors along with the continued commitment of our existing investors and founders emphasizes our momentum and progress in defining precision immuno-oncology for new patient segments.”

Juergen Eckhardt, MD, Head of Leaps by Bayer, commented, “Leaps by Bayer was founded to help solve ten of the world’s biggest challenges in health and agriculture, including preventing and curing cancer. We are thrilled to support NextPoint, an exciting addition to our oncology portfolio, as it works to redefine the treatment landscape of immuno-oncology.”

About NextPoint Therapeutics

About Bayer

Bayer is a global enterprise with core competencies in the life science fields of health care and nutrition. Its products and services are designed to help people and the planet thrive by supporting efforts to master the major challenges presented by a growing and aging global population. Bayer is committed to driving sustainable development and generating a positive impact with its businesses. At the same time, the Group aims to increase its earning power and create value through innovation and growth. The Bayer brand stands for trust, reliability and quality throughout the world. In fiscal 2021, the Group employed around 100,000 people and had sales of 44.1 billion euros. R&D expenses before special items amounted to 5.3 billion euros. For more information, go to www.bayer.com.

About Leaps by Bayer

Leaps by Bayer, a unit of Bayer AG, leads impact investments into solutions to some of today’s biggest challenges in health and agriculture. The investment portfolio includes more than 50 companies. They are all working on potentially breakthrough technologies to overcome some specific challenges such as, e.g., developing a sustainable protein supply, reducing the environmental impact of agriculture, preventing or curing cancer, and others. For more information, go to leaps.bayer.com.

About Sanofi Ventures

Sanofi Ventures is the corporate venture capital arm of Sanofi. Sanofi Ventures invests in early-stage biotech and digital health companies with innovative ideas and transformative new products and technologies of strategic interest to Sanofi. Among these areas are oncology, immunology, rare diseases, vaccines, potential cures in other core areas of Sanofi’s business footprint, and digital health solutions. Find out more: www.sanofiventures.com

Contacts

Media Contact

Lauren Arnold
MacDougall Advisors
1(617)694-5387
larnold@macdougall.bio

Kira Peikoff
Leaps by Bayer
1(973)791-3348
kira.peikoff@bayer.com

Zhao R, Chinai JM, Buhl S, et al. HHLA2 is a member of the B7 family and inhibits human CD4 and CD8 T cell function. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9879-84.
Janakiram M, Chinai JM, Fineberg S, et al. Expression, clinical significance, and receptor identification of the newest B7 family member HHLA2 protein. Clin Cancer Res. 2015 May 15;21(10):2359-66.
Wei Y, Ren X, Galbo PM Jr, et al. KIR3DL3-HHLA2 is a human immunosuppressive pathway and a therapeutic target. Sci Immunol. 2021 Jul 9;6(61):9792.
Bhatt RS, Berjis A, Konge JC, et al. KIR3DL3 Is an Inhibitory Receptor for HHLA2 that Mediates an Alternative Immunoinhibitory Pathway to PD1. Cancer Immunol Res. 2021 Feb;9(2):156-169.

Vice President, Translational Science

Summary

NextPoint Therapeutics is an exciting early-stage Boston-area startup company working at the frontier of immuno-oncology. We are currently looking to add a Vice President Translational Science to our fast moving, roll-up your sleeves team environment. Reporting to the Chief Medical Officer, the Vice President will build our Translational Medicine capability, responsible for managing research activities bridging from discovery to clinical development. The successful candidate will have a deep scientific knowledge and experience with oncology and immuno-oncology targets, biomarkers and animal models. The candidate will collaborate with Research and Clinical Development to develop and refine NextPoint’s clinical translational strategy and drive its effective implementation to support our clinical programs.

Responsibilities

Drive the clinical biomarker function to identify indications, support patient stratification and to inform on mechanism of action; develop, qualify, and execute biomarker assays with the most appropriate technical platforms to advance and support immune-oncology therapeutics to the clinic.
Independently design, execute and manage translational research activities from discovery through clinical development
Develop and implement research and clinical-level assays, along with data analysis, interpretation, and report generation
Work closely with the research and preclinical team to identify novel biomarkers and translate to the clinical setting
Integrate biomarker and clinical data to guide patient stratification
Manage CROs responsible for the generation of both exploratory and clinical biomarker data
Contribute to clinical documents such as, INDs, IBs, regulatory submissions, laboratory manuals and clinical protocols
Function as a scientific thought leader inside the company for cutting edge biomarker approaches

Experience and Qualifications

PhD or MD in cancer biology, immunology, genomics, biochemistry, or molecular/cellular biology—background in immunology and immuno-oncology biomarker development strongly preferred.
10+ years of pharmaceutical or biotechnology industry experience or mix of industry and academic experience in oncology or cancer immunotherapy with an emphasis on translational research, clinical biomarkers, and monoclonal antibodies
Proven track record of transitioning biomarkers from the bench to the clinic
Strong knowledge of immuno-oncology and associated biomarker approaches
Experience managing CROs
Technical expertise in IHC, RNAscope, flow cytometry, genetics (including ctDNA), RNA-Seq, NanoString, qPCR and ELISAs
Proven success with filing INDs and supporting clinical trials
Competency with bioinformatic datasets and experience collaborating with bioinformaticians to analyze publicly available datasets
Excellent communication and interpersonal skills, personal integrity, professional manner, and ability to gain respect and develop good working relationships with cross functional personnel at all levels
Ability to balance multiple stakeholders and projects simultaneously, and able to operate with high accountability and under tight deadlines
Forward looking thinker, who actively seeks opportunities and proposes solutions with strong decision-making capability
A collaborator who communicates in an open, clear, complete, timely and consistent manner who listens effectively and invites response and discussion

Medical Requirements

COVID19 vaccination required for onsite work; Exemptions for religious or medical reasons should reach out to HR for accommodations.

Applicants for the VP, Translational Science should reach out to Ashleigh Cunningham, acunningham@kleinhersh.com our staffing partner at Klein Hersh.

Associate Director/Director, Clinical Operations

Summary

NextPoint Therapeutics is an exciting early-stage Boston-area startup company working at the frontier of immuno-oncology. We are currently looking to add an Associate Director or Director, Clinical Operations to our fast moving, roll-up your sleeves team environment. Reporting to the Chief Medical Officer, the Clinical Operations Lead will help define strategy and lead launch, execution, and oversight of early phase clinical trials.

Responsibilities

Direct and run clinical operations and clinical trial launch activities for clinical programs
Manage clinical research organizations, clinical and testing lab vendors
Establish clinical operations infrastructure across the organization
Maintain relationships with Sites and KOLs
Represent NextPoint at Scientific and Investigator Meetings
Stay apprised of current trends in clinical trials research and regulatory landscape
Take responsibility for launch and day-to-day operational management of clinical trials including study sites
Participate in Clinical Vendor Governance and Safety Review Committee Meetings
Oversee all key study delivery functions

Experience and Qualifications

Bachelor of Science required, Masters of Science preferred. Degree in nursing, life sciences or a related discipline preferred.
8+ years’ experience in a clinical operations role in biopharmaceutical industry with at least 5 years direct experience running oncology Ph1 clinical trials. Experience with Ph 1-3 immuno-oncology clinical trials preferred.
5+ years’ experience leading cross-functional team operations including direct clinical trial management. Previous study start-up and clinical monitoring experience desired.
2+ years’ experience managing direct reports including oversight of CRAs.
Strong knowledge of pharmaceutical regulations e.g., GCP/ICH, GLP, GDPR, etc.
Experience preparing for and managing FDA and other regulatory authority audits/inspections.
Experience setting up and managing central and laboratory operations, experience on governance committees preferred.
Experience in managing CROs
3+ years’ experience establishing, managing, and maintaining trial master file applications e.g., Veeva Vault
5+ years’ experience with clinical databases e.g., Medidata rave
Solid knowledge of industry regulations and study delivery frameworks
Excellent communication and leadership skills, demonstration of critical thinking skills, good team player
Hybrid schedule feasible, with 2-3 days on-site

Medical Requirements

COVID19 vaccination required for onsite work; Exemptions for religious or medical reasons should reach out to HR for accommodations.

You can use the Easy Apply feature on LinkedIn – view job description.

Research Associate

Summary

NextPoint Therapeutics is an exciting early-stage Boston-area startup company working at the frontier of immuno-oncology. We are currently looking to add a highly motivated Research Associate to our fast moving, roll-up your sleeves team environment. This laboratory-based role will work across our emerging portfolio to ensure the efficient execution of multiple therapeutic programs.

Responsibilities

Design and perform ligand binding assays in multi-well formats to analyze novel antibody therapeutics
Develop and execute functional assays involving primary human immune cells, mammalian cell culture, and multi-color flow cytometry to screen novel antibody therapeutics in an immune-oncology setting
Work independently to design and conduct experiments, analyze, interpret, and communicate data in team meetings and to leadership
Support the laboratory organization and operations by maintaining lab equipment and managing reagent and supply inventories

Experience and Qualifications

Bachelor’s degree in cell/molecular biology, immunology, or cancer biology or equivalent field
2 + years hands-on experience in drug discovery research preferably in an industry setting
Experience with cell-based functional immune assays such as MLR, immune cell activity assays, and cytokine release assays
Experience with multiparameter flow cytometry
Hands on experience with murine tumor models preferred
Excellent verbal and written communication skills with a demonstrated ability to work collaboratively and thrive in a team environment
Excellent interpersonal skills and willingness to learn a variety of new techniques and technologies; flexibility to adapt to rapidly changing priorities and deadlines

Medical Requirements

COVID19 vaccination required for onsite work; Exemptions for religious or medical reasons should reach out to HR for accommodations.

Interested in finding out more?
Please send your resume and cover letter to HR@nextpointtx.com.

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24. Effective Date. The effective date of these Terms is May 18, 2022.

NextPoint Therapeutics, Inc. Privacy Notice

LAST UPDATED: May 18, 2022

This Privacy Notice is intended to describe how NextPoint Therapeutics, Inc., (“NextPoint”) collects, uses, and shares Personal Data that you submit to us and that we collect through our website https://www.nextpointtx.com (the “Site”). The Site provides a venue to obtain information about NextPoint, our activities, and products we may offer.

INFORMATION WE COLLECT

For purposes of this Privacy Notice, “Personal Data” means any information relating to an identified or identifiable natural person. As described in detail below, we may collect certain Personal Data from or about you in connection with your use of, or your submissions to, the Site.

We may collect Personal Data as follows:

When we leverage and/or collect cookies, device IDs, location, data from the environment, and other tracking technologies. We may collect certain Personal Data using cookies and other technologies, such as web beacons, device IDs, geolocation, HTML5 local storage, Flash cookies, and IP addresses. We specifically use browser cookies for different purposes, including cookies that are strictly necessary for functionality and cookies that are used for personalization and performance/analytics. When you visit the Site, we may also automatically collect certain data about your device, including information about your device’s operating system, your web browser, IP address, and time zone. Additionally, as you browse the Site, we collect information about the individual web pages or products that you view, what websites or search terms referred you to the Site, and information about how you interact with the Site. Our “Use of Cookies and Similar Technologies” section contains more information and options to control or opt-out of certain data collection or uses.

You are not required to provide all Personal Data identified in this Privacy Notice in order to use the Site; however, if you do not provide the Personal Data requested, we may be unable to provide some or all of the Site to you.

USE OF COOKIES AND SIMILAR TECHNOLOGIES

The Site uses cookies and similar technologies to improve user experience, for performance and analytics, and to improve our content, products, and services. We also use cookies and similar technologies for purposes of marketing and advertising.

A “cookie” is a small text file that a web server stores in browser software. A browser sends cookies to a server when the browser makes a connection to the server (for example, when requesting a web page from the same domain that created the cookie). The purpose of cookies is to remember the browser over time and distinguish one browser instance (or user) from all others. Some cookies and other technologies may serve to track Personal Data previously entered by a web user on our site. Most browsers allow you to control cookies, including whether or not to accept them, and how to remove them. Cookies can remember login information, preferences, and similar information.

Cookies, as well as other tracking technologies, such as HTML5 local storage, and Local Shared Objects (such as “Flash” cookies), and similar mechanisms, may record information such as a unique identifier, information you enter in a form, IP address, and other categories of data.

We may also use web beacons or “pixels,” and in certain circumstances may collect IP address, screen resolution and browser software and operating system types, clickstream patterns, dates and times that our site is accessed, and other categories of data.

If you want to block the use and saving of cookies from the Site on to the computers’ hard drive, you should take the necessary steps within your web browser’s settings to block all cookies from the Site and its external serving vendors, or use the cookie control system, if available upon first visit. Please note that if you choose to erase or block your cookies, certain parts of our Site may not function correctly. For information on how to disable cookies, refer to your browser’s documentation or documentation specific to certain types of cookies (for example Flash cookies and HTML5 cookies).

Our Site may use the following technologies to implement cookies and pixels:

Google Analytics. In order to ensure that the content from the Site remains up to date, user-oriented and comprehensive, this Site employs Google Analytics, a web-analysis tool from Google Inc. (“Google”) that enables us to optimize our Site for you. Google Analytics uses cookies that track your preferences during your visit to our Site. This allows us to simplify navigation, for example, thereby helping us to make the site more user-friendly. The information that is generated in this process (including the IP address) is anonymized, making personal identification impossible. An evaluation for reporting purposes is carried out only after the anonymization process. The data, generated by this Cookie are usually transferred and stored on a server in the USA. As a user of our Site, you always have the option of disabling cookies in your browser settings. Most browsers allow cookies as a default setting. Should you change this setting, this may disrupt certain functions of our Site. Furthermore, you can prevent Google’s acquisition and processing of the information that is generated by the cookie and concerns your activity on the Site (including your IP address) by downloading and installing a browser plug-in. In this process, your IP-Address is in a first step reduced to Countries in the European Union or other Countries in the European Economic Community. The actual link to the tool is: http://tools.google.com/dlpage/gaoptout?hl=us. Further information on the terms of use and the privacy options of Google are available on:
http://www.google.com/analytics/terms/us.html
Google AdWords. As an AdWords customer, the Site also uses Google conversion tracking by Google on some pages. This means that Google AdWords places a cookie on your computer (“conversion cookie”) if you have accessed our webpage via a Google ad. These cookies become invalid after 30 days. If you visit certain pages on our Site and the cookie has not yet expired, we and Google can recognize that someone has clicked on an ad and been directed to our page as a result thereof. Each AdWords customer receives a different cookie. Cookies can therefore not be tracked via the websites of AdWords customers. The information collected with the help of the conversion cookie allows us to prepare conversion statistics to optimize our services. AdWords customers know, for instance, the total number of customers who have clicked on their ad and been redirected to a page with a conversion tracking tag. But they do not receive any information by which users can be personally identified. If you do not want to participate in the tracking, you can prevent the placement of the necessary cookie – for instance through a browser setting that deactivates the automatic placement of cookies in general. “You can also deactivate conversion tracking cookies by setting your browser to block cookies from the domain googleadservices.com”.
Google Remarketing. Moreover, the Site uses Google’s Remarketing technology on some pages. With this technology, users who have already visited our web pages and online services and shown in interest in what we have to offer are shown targeted advertising on other websites of the Google Partner network. The ads are displayed through the use of cookies, by means of which the user’s behavior during his or her visit to the website is analyzed and then used for targeted product recommendations and interest-based advertising.

If you do not wish to receive any interest-based advertising, you can deactivate Google’s use of cookies for these purposes by going to https://www.google.com/settings/ads. Alternatively, users can deactivate cookies from third-party providers by going to the network advertising initiative’s deactivation page (link: https://optout.networkadvertising.org/?c=1).

Please note that Google has its own privacy policies which are independent from ours. We do not accept any responsibility or liability for these policies and procedures. Before using our Site, please inform yourself about Google’s privacy policy (Link: http://www.google.com/privacy.html).

HOW WE USE THE INFORMATION WE COLLECT

We may use Personal Data for a variety of different purposes as set out in further detail below. Subject to applicable law, the purposes for which we use and process Personal Data, and the legal basis for such processing, are set forth below.

For our legitimate business Interests. To operate our business and provide the Site, other than in performing our contractual obligations to you, for our legitimate business interests for the purposes of applicable law, except where such interests are overridden by the interests or fundamental rights and freedoms of the data subject which require protection of personal data. Legitimate interests may include:
- To maintain the Site, including for technical support;
- To communicate with you regarding the Site, including to provide you important notices regarding changes to our Terms of Use;
- To address and respond to your requests, inquiries, and complaints;
- To develop, provide, and improve the Site, including to better tailor the features, performance, security and support of the Site, and for statistical and analytics purposes;
- For our direct marketing purposes;
- In any other way we may describe when you provide the information;
- For any other purpose with your consent;
- For fraud, loss, and other crime prevention purposes;
- To assist in the investigation of suspected illegal or wrongful activity, and to protect and defend our rights and property, or the rights or safety of third parties;
- To enforce our Terms of Use, this Privacy Notice, or agreements with third parties;
- To comply with laws, regulators, court orders, or other legal obligations, or pursuant to legal process; or
- Subject to applicable contractual or legal restrictions, in connection with a contemplated reorganization or an actual reorganization of our business, in connection with financing, a sale or other transaction involving the disposal of all or part of our business or assets, including for the purpose of permitting the due diligence required to decide whether to proceed with a transaction.
To comply with legal obligations. To comply with laws, regulators, court orders, or other legal obligations, or pursuant to legal process.
To protect data subjects’ vital interests. To protect the vital interests of you or of another person.

In some cases where we are not already authorized to process the Personal Data under applicable law, we may ask for your consent to process your Personal Data:

Special Categories of Personal Data. We generally do not collect or require special categories of Personal Data (such as racial or ethnic origin, political opinions, religious or philosophical beliefs, trade union membership, health information, biometric data, or sexual orientation) in order to access our Site. In the event you voluntarily provide this information to us or we need to collect such information to provide a specific service to you, we will obtain your consent if required by law. If you choose not to provide consent, you may not be able to access all of the features and content of our Site. In certain circumstances, subject to applicable law, we may process or otherwise disclose special categories of Personal Data without consent, such as to protect the vital interests of you or of another person.
Cookies. We may also request consent for some cookies in accordance with our cookie policy.

HOW WE MAY DISCLOSE INFORMATION

We may disclose Personal Data as described in this Privacy Notice, including:

For the Purpose Disclosed. We may disclose your Personal Data to fulfill the purpose for which you provided it to us.
Affiliates. We may disclose some or all of your Personal Data to our subsidiaries, joint ventures, and other companies under our common control (collectively, “Affiliates”), for the purposes described in this Privacy Notice. Where we share Personal Data with our Affiliates, we will require our Affiliates to honor this Privacy Notice.
Service Providers. We may disclose Personal Data to business partners, distributors, service providers, marketing partners, and vendors in order to maintain, provide and improve the Site. We may also share Personal Data for other technical and processing functions, such as sending e-mails on our behalf, technical support, or otherwise operating the Site, for analytics, and for marketing purposes. Such third parties may have access to Personal Data only as needed to perform their functions for us, and they may not use Personal Data for other purposes.
Pursuant to Legal Process and Protection of Rights. We may also disclose Personal Data to comply with applicable laws and regulations, to respond to a subpoena, search warrant, or other lawful request for information we receive, or as otherwise pursuant to legal process. We may also use and disclose Personal Data to establish or exercise our legal rights, to enforce our Terms of Use, this Privacy Notice, or agreements with third parties, to assert and defend against legal claims, or if we believe such disclosure is necessary to investigate, prevent, or take other action regarding actual or suspected illegal or fraudulent activities or potential threats to the physical safety or well-being of any person.
Corporate Transactions. Subject to applicable law, we reserve the right to sell or transfer Personal Data in the event that we are acquired by or merged with another company or in connection with the potential sale or transfer of some or all of the business assets of the Site or NextPoint, including for the purpose of permitting the due diligence required to decide whether to proceed with a transaction. If the sale occurs, the purchaser will be entitled to use and disclose the Personal Data collected by us, and the purchaser will assume the rights and obligations regarding Personal Data as described in this Privacy Notice.
Consent. We may also disclose Personal Data with your consent.

DE-IDENTIFIED OR ANONYMOUS DATA

We may create de-identified or anonymous data from Personal Data by removing data components (such as your name, email address, or linkable tracking ID) that make the data personally identifiable to you or through obfuscation or through other means. Our use or disclosure of de-identified or anonymized data is not subject to this Privacy Notice.

DO-NOT-TRACK

Do-Not-Track is a public-private initiative that has developed a “flag” or signal that an Internet user may activate in the user’s browser software to notify websites that the user does not wish to be “tracked” by third-parties as defined by the initiative. The online community has not agreed on what actions, if any, should be taken by the websites that receive the “do not track” signal, and therefore Do-Not-Track is not yet standardized. Please note that the Site does not alter its behavior or use practices when we receive a Do Not Track signal from your browser.

INFORMATION FROM CHILDREN UNDER 13 YEARS OF AGE

We do not knowingly collect information from minors under the age of 13 years without parental consent. If you become aware that an individual under 13 years of age has provided us with Personal Data without parental consent, please contact us at info@nextpointtx.com. If we become aware that an individual under 13 years has provided us with Personal Data without parental consent, we will take steps to remove the data as permitted by law.

LINKS TO OTHER SITES

Our Site may contain links or otherwise provide access to another website, mobile application, or Internet location (collectively “Third-Party Sites”). We provide these links merely for your convenience. We have no control over, do not review, and are not responsible for Third-Party Sites, their content, or any goods or services available through the Third-Party Sites. Our Privacy Notice does not apply to Third-Party Sites. We encourage you to read the privacy policies of any Third-Party Site with which you choose to interact.

CALIFORNIA RESIDENTS

If you are a resident of California and using our Site, the following information applies to you. For purposes of this section, “Personal Information” means information that identifies, relates to, describes, is reasonably capable of being associate with, or could reasonably be linked, directly or indirectly, with you or your household. Personal Information does not include publicly available information, information that is de-identified, aggregated information, or any other information outside the scope of the California Consumer Privacy Act of 2018 (“CCPA”).

We may collect Person Information from you in a variety of ways:

Category of Personal Information	Categories of Sources	Purpose of Collecting/Sharing	Categories of Third Parties to Whom We Disclose Personal Information
Personal identifiers such as name, date of birth, email address, IP address, account name, online identifier, social security number, license number or other similar identifiers	You, your computer and mobile devices when you access our Site	To allow you access to our Site and to provide you with services, such as responding to questions you may have	Third parties that help us administer and manage our Services, including third parties that help us manage our communications, complete transactions, assist with our information technology and security programs, our lawyers, accountants, auditors, or regulatory bodies or other third parties as may be required by law.
Protected classification characteristics under California or federal law such as age, gender, gender identity, gender expression, health information, education	N/A	We do not generally collect this information	N/A
Commercial information, such a Services provided, your interaction with our Site and Services	You	To allow you access to our Services, to provide you with Services, to respond to questions you may have	Third parties that help us administer and manage our Services, including third parties that help us manage our communications, complete transactions, assist with our information technology and security programs, our lawyers, accountants, auditors, or regulatory bodies or other third parties as may be required by law.
Biometric Information	N/A	We do not generally collect this information	N/A
Internet or other similar network activity information such as browsing history, login information, device type, accounts, IP address and other similar information concerning your interactions with our Site.	Your computer and mobile devices when you visit our Site. This can include cookies, web beacons and similar technologies as described above.	To analyze and improve our Services, administer our Site and Services, provide you with access to our Services, analyze and improve our information technology, monitor compliance with our Terms of Use, and enforce our Terms of Use or other legal or regulatory obligations	Third parties that help us administer and manage our Services, including third parties that help us manage our communications, complete transactions, assist with our information technology and security programs, our lawyers, accountants, auditors, or regulatory bodies or other third parties as may be required by law.
Geolocation Data such as physical location information that may be provided by the device you are using	Your computer and mobile devices when you access our Site.	To analyze and improve our Services, administer our Site and Services, provide you with access to our Services, analyze and improve our information technology, monitor compliance with our Terms of Use, and enforce our Terms of Use or other legal or regulatory obligations.	Third parties that help us administer and manage our Services, including third parties that help us manage our communications, complete transactions, assist with our information technology and security programs, our lawyers, accountants, auditors, or regulatory bodies or other third parties as may be required by law.
Audio, electronic, visual, thermal, olfactory or similar information	N/A	We generally do not collect this type of information	N/A
Inferences drawn from other Personal Information	You	To analyze and improve our Services, administer our Site and Services, provide you with access to our Services, analyze and improve our information technology, monitor compliance with our Terms of Use, and enforce our Terms of Use or other legal or regulatory obligations	Third parties that help us administer and manage our Services, including third parties that help us manage our communications, complete transactions, assist with our information technology and security programs, our lawyers, accountants, auditors, or regulatory bodies or other third parties as may be required by law.

Exercising your Rights under CCPA

If you wish to exercise your rights under California law, please see the “Right to Access and Control Your Personal Information Under the European Union Data Protection Regulation (GDPR) and CCPA” section below for information on how to contact us to exercise your rights.

NextPoint does not sell your Personal Information.

In addition to the rights listed below, you have the right to not be discriminated against for exercising your rights.

Only you or a person registered with the California Secretary of State that you authorize to act on your behalf, may make a verifiable consumer request related to your personal information.

You may only make a verifiable consumer request for access or data portability twice within a 12-month period. The verifiable consumer request must:

Provide sufficient information that allows us to reasonably verify you are the person about whom we collected personal information or an authorized representative.
Describe your request with sufficient detail that allows us to properly understand, evaluate, and respond to it.

California Shine the Light Law:

California Civil Code Section 1798.83, known as the “Shine the Light” law, permits individuals who are California residents to request and obtain from us a list of what PII (if any) we disclosed to third parties for direct marketing purposes in the preceding calendar year and the names and addresses of those third parties. We will never disclose your PII to third parties for direct marketing purposes without your authorization. However, if you would like to make a request for information under the Shine The Light law, please contact us at the “Contact Us” section below.

Requests may be made only once a year and are free of charge.

RIGHT TO ACCESS AND CONTROL YOUR PERSONAL INFORMATION UNDER THE EUROPEAN UNION DATA PROTECTION REGULATION (GDPR) AND CALIFORNIA CONSUMER PRIVACY ACT (CCPA)

Individuals in California, the EU and certain other jurisdictions who are accessing this site and whose data we may be collecting and processing may have certain rights under applicable data protection law, including the right to request confirmation from us as to whether or not we are processing your Personal Data. Where we are processing your Personal Data, subject to applicable law, you also have the right to:

Request access to, modification or rectification, or deletion. You may have the right to request access to, modification of, correction of, or deletion of your Personal Data we maintain.
Request restriction of processing. You may have the right to request that we restrict processing of your Personal Data in certain circumstances, such as where you believe that the Personal Data we hold about you is inaccurate or our processing is unlawful.
Object to processing. In certain circumstances, you may have the right to request that we stop processing your Personal Data, such as a request to stop sending you direct marketing communications. To opt-out of direct marketing communications, please see the instructions in the “Withdrawing Your Consent” section of this Privacy Notice.
Data portability. In certain circumstances, you may have the right to receive the Personal Data concerning you that you provided to us or to request that we transmit your Personal Data to another data controller.
Lodge a Complaint. You have the right to lodge a complaint with a supervisory authority.

To exercise your rights, you may contact us as at info@nextpointtx.com. As permitted by law, certain data elements may not be subject to access, modification, portability, restriction, and/or deletion. Furthermore, where permissible, we may charge for this service. We will respond to reasonable requests as soon as practicable and as required by law. To protect your privacy and security, we may take steps to verify your identity in order to respond to your request. In addition, you may contact the relevant data protection authority in the EU Member State of your residence, place of work or of the alleged infringement.

WITHDRAWING YOUR CONSENT

In most cases, we need to process certain components of your Personal Data in order to fulfill our contractual obligations to you and for our legitimate interests. Please note that, subject to applicable law, we may continue to process your Personal Data even where you object if there are compelling legitimate grounds for processing that override your interests and rights, or where processing is necessary to establish, exercise, or defend legal claims.

Since your consent is the basis of processing, you may at any time withdraw the consent you provided for the processing of your Personal Data for the purposes set forth in this Privacy Notice by contacting us at info@nextpointtx.com, provided that we are not required by applicable law or professional standards to retain such information.

If you would like to stop receiving newsletters or other marketing or promotional messages, notifications, or updates, you may do so by following the unsubscribe instructions that appear in these e-mail communications. Alternatively, you may contact us at info@nextpointtx.com to opt-out of direct marketing. Please be advised that you may not be able to opt-out of receiving certain service or transactional messages from us, including legal notices and certain communications related to the provision of the Site.

Please note that if you do not provide consent, if you withdraw your consent or object to processing, or if you choose not to provide certain Personal Data, we may be unable to provide you some or all of the Site.

TRANSFER OF DATA

Please note that if you are visiting the Site from outside of the United States, your information may be transferred to, stored, and/or processed in the US. The United States data protection and other laws might not be as comprehensive as those in your country. If you are located outside of the United States, the transfer of Personal Data is necessary to provide you with the requested information and Site and/or to perform any requested transaction. By using any portion of the Site, you acknowledge and consent to the transfer of your information to our facilities in the United States.

DATA RETENTION

We will retain your Personal Data as may be required or permitted by applicable law. We will also retain your Personal Data as necessary to comply with our legal obligations, resolve disputes, and enforce our agreements.

SECURITY

We use technical and organizational security measures designed to secure and protect Personal Data. Please note, however, we cannot fully eliminate security risks associated with the storage and transmission of Personal Data.

UPDATES TO THIS PRIVACY NOTICE

We may update this Privacy Notice from time to time. The most recent version of the Privacy Notice is reflected by the version date located at the top of this Privacy Notice. We encourage you to review this Privacy Notice often to stay informed of how we may process your information.

CONTACT US

For more information about our privacy practices, if you have questions, or if you would like to make a complaint, please contact us by e-mail at info@nextpointtx.com or by mail at the following address:

NextPoint Therapeutics, Inc.
450 Kendall Street
Cambridge, MA 02142

Detlev Biniszkiewicz, PhD

Paul Conrad, PhD, MBA

Leena Gandhi, MD, PhD

Axel Hoos, MD, PhD, Joins NextPoint Therapeutics Board of Directors

NextPoint Therapeutics Appoints Leena Gandhi, MD, PhD, as Chief Medical Officer

NextPoint Therapeutics Announces $80 Million Series B Financing co-led by Leaps by Bayer and Sanofi Ventures to Advance Novel Immuno-Oncology Programs

Vice President, Translational Science

Associate Director/Director, Clinical Operations

Research Associate

NextPoint Therapeutics Terms of Use

NextPoint Therapeutics, Inc. Privacy Notice